Biopolymeric nanoparticles, There are numerous biopolymeric materials that are utilized in the drug delivery systems.
> Polymeric micelles
Nanostructures made of amphiphilic block copolymers that gather by itself to form a core shell structure in the aqueous solution. Polymeric micelles are under 100 nm in size and their polymeric shell restrains nonspecific interactions with biological components. These nanostructures have a strong prospective for hydrophobic drug delivery since their interior core structure permits the assimilation of these kind of drugs resulting in enhancement of stability and bioavailability [1, 2].
Synthesis of polymeric micelles
Polymeric micelles are synthesized by two approaches: (1) convenient solvent-based direct dissolution of polymer followed by dialysis process or (2) precipitation of one block by adding a solvent [2,3]. The factors like hydrophobic chain size in the amphiphilic molecule, amphiphiles concentration, solvent systems and temperature, affects the micelle formation . The micelle assembly creation starts when minimum concentration known as the critical micelle concentration (CMC) is reached by the amphiphilic molecules . At lower concentrations, the amphiphilic molecules are indeed small and occur independently .
Drugs and polymeric micelles
Drugs are loaded within polymeric micelles by three common methodologies such as dissolution process, solvent evaporation process, and the dialysis process. As of the direct dissolution process, the copolymer and the drugs combine with each other by themselves in the water medium and forms a drug loaded with the micelles. While in the solvent evaporation process, the copolymer and the intended drug is dissolved using a volatile organic solvent and finally, in case of the dialysis process, both the drug in solution and the copolymer in the organic solvent are combined in the dialysis bag and then dialyzed with the formation of the micelle 
Drugs target using polymeric micelles
The targeting of the drugs using different polymeric micelles as established by various mechanism of action including the boosted penetrability and the holding effect stimuli :
- Complexing of a definite aiming ligand molecule to the surface of the micelle
- Combination of the monoclonal antibodies to the micelle corona
Potentials of polymeric micelles
Polymeric micelles are reported to be applicable for both drug delivery against cancer  and also for ocular drug delivery  In the work by Li et al. , dasatinib was encapsulated within nanoparticles prepared from micellation of PEG-b-PC to treat proliferative vitreo-retinopathy (PVR), their size was 55 nm with a narrow distribution and they turned out to be noncytotoxic to ARPE-19 cells. This micellar formulation ominously repressed the cell proliferation, attachment and relocation in comparison to the free drugs . The polymeric micelles is habitually get into the rear eye tissues through the transcleral pathway after relevant applications.
 Miyata K, Christie RJ, Kataoka K. Polymeric micelles for nano‑scale drug delivery. React Funct Polym. 2011;71:227–34. 142.
 Xu W, Ling P, Zhang T. Polymeric micelles, a promising drug delivery system to enhance bioavailability of poorly water‑soluble drugs. J Drug Deliv. 2013;2013:340315. 143.
 Kulthe SS, Choudhari YM, Inamdar NN, Mourya V. Polymeric micelles: authoritative aspects for drug delivery. Design Monomers Polym. 2012;15:465–521.
 Devarajan PV, Jain S. Targeted drug delivery: concepts and design. Berlin: Springer; 2016. 145.
 Mourya V, Inamdar N, Nawale R, Kulthe S. Polymeric micelles: general considerations and their applications. Ind J Pharm Educ Res. 2011;45:128–38. 146.
 Wakaskar RR. Polymeric micelles for drug delivery. Int J Drug Dev Res. 2017;9:1–2. 147.
 Mandal A, Bisht R, Rupenthal ID, Mitra AK. Polymeric micelles for ocular drug delivery: from structural frameworks to recent preclinical studies. J Control Release. 2017;248:96–116.
 Li Q, Lai KL, Chan PS, Leung SC, Li HY, Fang Y, To KK, Choi CHJ, Gao QY, Lee TW. Micellar delivery of dasatinib for the inhibition of pathologic cellular processes of the retinal pigment epithelium. Coll Surf B. 2016;140:278–86.