Authors: André Koga Salles and Gabrielle Gimenes Lima (FEBRAF, Brazil)
Cholesterol is a precursor lipid in the biosynthesis of bile and steroid hormones, such as testosterone and progesterone. The lipid in question is obtained mainly through its synthesis in the liver and intestine  from the molecules CoA and "acetoacetyl-CoA", where this process is regulated according to cholesterolemia .
Cholesterol is transported by lipoproteins since it is insoluble in the blood . The transporter lipoproteins can be classified as “Low-Density Lipoproteins” (LDL) or “High-Density Lipoproteins” (HDL), where the first is responsible for the delivery of the metabolite synthesized by the liver to other tissues while the second performs the return of cholesterol from cells to the original organ.
However, a picture of excess current LDL is called hypercholesterolemia and it favors the agglutination of the lipid to the artery walls, resulting in the obstruction of blood flow and, consequently, an increase in blood pressure. The clinical case corresponding to this accumulation is known as atherosclerosis  and is initially asymptomatic. However, the deposition site is directly related to the severity of the condition, because if the agglutination is located in the brain or coronary arteries, the likelihood of infarction or cerebral hemorrhage (stroke) is increased . or coronary arteries, the likelihood of infarction or cerebral hemorrhage (stroke) is increased . or coronary arteries, the likelihood of infarction or cerebral hemorrhage (stroke) is increased ,infarction or cerebral hemorrhage (stroke) is increased .
Therefore, the occurrence of atherosclerosis is favored in cases of hypercholesterolemia and with this, in mind, it is possible to place preventive measures against this disease, among them we have:
• Perform physical activity .
• Stop smoking .
• Follow a diet recommended by a health professional adapted to each organism, in addition to always looking for qualified health professionals to assist in the administration of medications, if necessary, and to carry out a food-pharmacotherapeutic follow-up.
The pharmacist is a qualified professional to perform the dispensing and administration of medications, this specialist will be responsible for monitoring the patient and providing guidance on the proper use of each drug.
Although there is no effective cure for atherosclerosis, there are drugs on the market capable of delaying and preventing possible worsening of the condition, to prevent deposition in vital organs and damage them . For this, statin drugs are used to regulate the production of cholesterol by the liver and the most relevant drugs of this nature are:
• Atorvastatin ;
• Lovastatin ;
• Pravastatin ;
• Rosuvastatin .