Recently, a publication was made regarding a novel system called LYTAC (lysosome-targeting chimaeras).
This method was based on a relatively recent therapeutical system called PROTAC (proteasome-targeting chimaeras). Basically this system targets a certain protein and degrades it by using endosome machinary.
Truth to be told, I was not aware of this technology before, but I think this could be interesting in the future. Let me know if anyone has any opinion on this or if someone is involved in this type of system development project, it would be nice if you can share with us.